Remdesivir

Remdesivir
Data klinikal
Nama lain	GS-5734
Kaedah; pemberian	Intravena
Kod ATC	Tiada;
Pengecam
	Nama IUPAC (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester;
Nombor CAS	1809249-37-3 ;
PubChem CID	121304016;
DrugBank	DB14761 ;
ChemSpider	58827832;
UNII	EW5GL2X7E0;
KEGG	D11472;
ChEBI	CHEBI:145994;
CompTox Dashboard (EPA)	DTXSID701022537 ;
ECHA InfoCard	100.302.974
Data kimia dan fizikal
Formula	C27H35N6O8P
Jisim molar	602.58 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CCC(COC(=O)[C@@H](NP(=O)(Oc1ccccc1)OC[C@H]1O[C@@]([C@@H]([C@@H]1O)O)(C#N)c1ccc2n1ncnc2N)C)CC;
	InChI InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1; Key:RWWYLEGWBNMMLJ-YSOARWBDSA-N;

Remdesivir (kod GS-5734) ialah sejenis ubat antivirus dalam jenis analog nukleotida. Ubat ini dihasilkan oleh Gilead Sciences sebagai rawatan terhadap penyakit virus Ebola dan jangkita virus Marburg.^[1] Namun begitu, ubat ini didapati dapat menjadi ubat antivirus terhadap virus-virus RNA berbenang tunggal yang lain.^[2] Remdesivir kini dikaji untuk merawat jangkitan SARS-CoV-2 and Henipavirus.^[3]^[4]^[5] Permohonan paten berkaitan Veklury® menyatakan bahawa selain 100 mg bahan aktif remdesivir, kuantiti sebanyak 3 atau 6 g sulfobutylether-beta-cyclodextrin, jenama Captisol® yang dihasilkan oleh Ligand Pharmaceuticals (San Diego, USA) dan jenama Dexolve® yang dihasilkan oleh CycloLab Ciklodextrin R&D Laboratory Ltd. (Budapest, Hungary), telah digunakan sebagai agen pemelarutan. ^[6]

Rujukan

^ Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, dll. (March 2016). "Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys". Nature. 531 (7594): 381–5. doi:10.1038/nature17180. PMC 5551389. PMID 26934220.
^ Lo MK, Jordan R, Arvey A, Sudhamsu J, Shrivastava-Ranjan P, Hotard AL, dll. (March 2017). "GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses". Scientific Reports. 7 (1): 43395. Bibcode:2017NatSR...743395L. doi:10.1038/srep43395. PMC 5338263. PMID 28262699.
^ Brunk, Doug. "Remdesivir Under Study as Treatment for Novel Coronavirus". Medscape. Dicapai pada 11 Februari 2020. Unknown parameter |name-list-format= ignored (bantuan)
^ "Experimental Ebola drug 'remdesivir' may help protect against Nipah virus, say scientists". Times Now Digital. 3 Jun 2019.
^ The Wire Staff (2 Jun 2019). "Scientists Claim Drug Designed to Beat Ebola Also Fights Off Nipah". The Wire.
^ https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019014247&tab=PCTDESCRIPTION&_cid=P10-K9CEQ6-50723-1

Pautan luar

Kategori berkenaan Remdesivir di Wikimedia Commons

Rencana berkenaan kimia ini ialah rencana tunas. Anda boleh membantu Wikipedia dengan mengembangkannya.

[Nature_Warren_20160317-1] Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, dll. (March 2016). "Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys". Nature. 531 (7594): 381–5. doi:10.1038/nature17180. PMC 5551389. PMID 26934220.

[2] Lo MK, Jordan R, Arvey A, Sudhamsu J, Shrivastava-Ranjan P, Hotard AL, dll. (March 2017). "GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses". Scientific Reports. 7 (1): 43395. Bibcode:2017NatSR...743395L. doi:10.1038/srep43395. PMC 5338263. PMID 28262699.

[3] Brunk, Doug. "Remdesivir Under Study as Treatment for Novel Coronavirus". Medscape. Dicapai pada 11 Februari 2020. Unknown parameter |name-list-format= ignored (bantuan)

[4] "Experimental Ebola drug 'remdesivir' may help protect against Nipah virus, say scientists". Times Now Digital. 3 Jun 2019.

[5] The Wire Staff (2 Jun 2019). "Scientists Claim Drug Designed to Beat Ebola Also Fights Off Nipah". The Wire.

[6] ttps://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019014247&tab=PCTDESCRIPTION&_cid=P10-K9CEQ6-50723-1

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Data klinikal

Nama lain	GS-5734
Kaedah pemberian	Intravena
Kod ATC	Tiada
Pengecam
Nama IUPAC (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
Nombor CAS	1809249-37-3^Y
PubChem CID	121304016
DrugBank	DB14761^Y
ChemSpider	58827832
UNII	EW5GL2X7E0
KEGG	D11472
ChEBI	CHEBI:145994
CompTox Dashboard (EPA)	DTXSID701022537
ECHA InfoCard	100.302.974
Data kimia dan fizikal
Formula	C₂₇H₃₅N₆O₈P
Jisim molar	602.58 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES CCC(COC(=O)[C@@H](NP(=O)(Oc1ccccc1)OC[C@H]1O[C@@]([C@@H]([C@@H]1O)O)(C#N)c1ccc2n1ncnc2N)C)CC
InChI InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1 Key:RWWYLEGWBNMMLJ-YSOARWBDSA-N